FINAL PRIORITIZED CANDIDATE CHEMICALS UNDER CONSIDERATION FOR CARCINOGENICITY EVALUATION: FIVE CHEMICALS WITHIN BATCH #3 Office of Environmental Health Hazard Assessment California Environmental Protection Agency

Final data summaries are available for the five remaining chemicals (lovastatin, methylphenidate and its hydrochloride (Ritalin), phenelzine and its acid salts, styrene, and tetrachlorvinphos) out of the 60 chemicals under consideration for carcinogenicity evaluation (Batch #3). Batch #3 chemicals were selected for prioritization from Category I of the tracking database by the process described in the document entitled “Procedure for Prioritizing Candidate Chemicals for Consideration under Proposition 65 by the State's Qualified Experts” (May 1997). One batch of 60 chemicals was selected in a second round pilot random selection from among 100 within Category I of the tracking database for which toxicity information had been entered into the toxicity field of the data entry sheet. On February 19, 1999, OEHHA announced the release of draft priority assignments and draft data summaries for 59 of 60 chemicals selected for prioritization with respect to their potential to cause cancer. The prioritization of one chemical, bis(4-chlorophenyl)sulfone, has been postponed pending the results of a bioassay expected in the next one to two years from the National Toxicology Program. The February 19, 1999, announcement initiated a 60-day public comment period, which included a public workshop held April 9, 1999. Fifty-four of the 59 priority assignments were finalized and announced in the California Regulatory Notice Register 99, No. 32-Z August 6, 1999. Review and careful consideration of the comments received on the remaining five chemicals has now been completed and the priority assignments have been finalized. The only final priority which differs from the draft assignment is for methylphenidate and its hydrochloride (Ritalin), for which the final priority is “not high” enough to merit placement on the Candidate List. Revisions have been made to the text of some data summaries as a result of comments.